
Bake in a preheated 400˚F oven until the cheese is bubbling and it is golden brown on top, about 20 minutes. Sprinkle the Parmesan-bread crumb topping evenly over the macaroni and cheese. Melt the remaining 2 tablespoons of butter (you can use the microwave) and mix with the Parmesan cheese, breadcrumbs, parsley, and some salt and pepper. Stir in the drained macaroni noodles, and then transfer to a baking dish. Whisk in the Cheddar, Gouda, mustard, garlic powder, 1 teaspoon salt, and 1/2 teaspoon pepper, and stir until the cheese has melted and everything is evenly combined. Add in the milk, increase the heat, and cook, whisking regularly, until the milk comes to a boil and thickens, 5 to 10 minutes. Whisk in the flour and cook for about 1 minute. Melt 2 tablespoons butter in a pot over medium heat.
Whisk in salt, onion powder, garlic powder, and mustard powder seasonings. Whisk in the 4 cups of milk 1 cup of the milk at a time making sure the mixture is lump free. Bake until the topping is browned and the macaroni is hot, about 20 minutes. Melt the remaining 2 tablespoons butter and toss with the bread crumbs distribute over the macaroni.
Sprinkle evenly with the remaining Cheddar and Parmesan. Add flour and cook, constantly stirring with a whisk, for 1 minute. Pile into a 13 by 9-inch baking dish or four 6-inch cast-iron skillets.
Cook the pasta in boiling salted water until al dente (cooked, but still retains some bite). In a large saucepan, melt 8 tbsp unsalted butter over medium heat.